Contacts et personnels
Gordon Langsley, PhD
Head of lab: “Comparative Cell Biology of Apicomplexa Parasites”.
Academic Editor PLoS One
Biology Editor Parasite (Journal of the French Society of Parasitology)
Editorial Board Member Molecular Microbiology (Wiley-Blackwell)
Editorial Board Member Transboundary Emerging Diseases (Wiley-Blackwell)
The laboratory’s research focus is in host-parasite signalling interactions in two Apicomplexa parasites of medical importance: Plasmodia and Theileria. We are particularly interested in signalling pathways that regulate oxidative stress and autophagy. In the case of Theileria our focus is on leukocyte signalling pathways that regulate the oxidative stress and how the degree of ROS influences the switch from OXPHOS to Warburg glycolysis. We are also studying how Theileria parasites suppress host cell autophagy. In Plasmodium-infected red blood cells we focus on how cAMP regulates the oxidative stress status of the infected erythrocyte and also the regulation of Rab-mediated vesicular traffic; particularly, in the context of anti-malarial drug treatment and parasite death by autophagy.
Jean Dupouy-Camet, MD, PhD, DTM&H (Paris)
Professeur de Parasitologie et Mycologie Médicale à la Faculté et chef du Service de Parasitologie-Mycologie de l’hôpital Cochin. Ancien Secrétaire général de la Société Française de Parasitologie et ancien président de la Commission internationale sur la Trichinellose. Actuel président de la Fédération Européenne de Parasitologie
Thème de recherche :
Compte tenu des ses activités d’enseignement, de ses responsabilités administratives et cliniques, ses activité de recherche dans l’unité se bornent à être un «stimulus clinique».
||Hélène Yera, MD-Pharma, PhD, HDR
Over and above her research activity, Hélène has both clinical and teaching duties in the Parasitology-Mycology Clinical Service of the Cochin Hospital.
Hélène directed two M2 and one PhD students who studied the role of Rab5A, Rab5B and Rab5C in haemoglobin uptake by Plasmodium, using reverse genetics and protein-protein interaction technology. This led to a model of haemoglobin uptake that is Rab5A- and Rab5C-, but not Rab5B-dependant. After uptake, haemoglobin degradation in the food vacuole generates oxidative stress that is detrimental for the parasite. Her project aims to study how the parasite antioxidant enzyme (iron superoxide dismutase 1, SOD1) is involved in management of oxidative stress stemming from haemoglobin degradation.
Jessie Whitworth: a 3rd year Chemistry student studying at the University of Leeds who as part of her MChem joined the laboratory for her industrial placement year.
Research project: collaboration with Professor Michel Vidal, Pharmacy Faculty
The project uses chemical genetics to dissect the virulence of Theileria-infected macrophages. The expression of Grb-2 and Gab1 is down-regulated in attenuated macrophages that have lost their virulent, disseminating phenotype. Michel Vidal (PU-PH) in the Pharmacology department has synthesized a Grb2 competing peptide (peptide-C), which blocks binding to the SH3 domain of Grb2 and therefore, will ablate Gab1 binding. Jessie is testing whether ablation of the Gab1-Grb2 interaction leads to loss of Theileria-infected macrophages virulence.
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